The screen of TimTec compounds identified 6 potent TNF-alpha inducers, which are available from our stock.
Identification of novel formyl peptide receptor-like 1 agonists that induce macrophage tumor necrosis factor alpha production. Schepetkin IA, Kirpotina LN, Tian J, Khlebnikov AI, Ye RD, Quinn MT. Mol Pharmacol. 2008 Aug;74(2):392-402.
Abstract
Download TNF-alpha inducers analogs
Chemical structures of the most potent TNF-? inducers
MW 370.21 MF C17H12BrN3O2 N-{(1E)-2-[5-(3-bromophenyl)(2-furyl)]-1-azavinyl}-3-pyridylcarboxamide |
MW 376.31 MF C19H12F4N2O2 N-((1Z)-2-{5-[3-(trifluoromethyl)phenyl](2-furyl)}-1-azavinyl)(4-fluorophenyl) carboxamide |
ST020520
MW 404.42 MF C23H20N2O5 2H-benzo[3,4-d]1,3-dioxolan-5-yl-N-{(1Z)-2-[3-methoxy-4-(phenylmethoxy)phenyl] -1-azavinyl}carboxamide |
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MW 359.21 MF C18H12Cl2N2O2 N-{(1E)-2-[5-(2,3-dichlorophenyl)(2-furyl)]-1-azavinyl}benzamide |
MW 413.77 MF C19H12ClN3O6 2H-benzo[3,4-d]1,3-dioxolan-5-yl-N-{(1Z)-2-[5-(2-chloro-4-nitrophenyl)(2-furyl )]-1-azavinyl}carboxamide |
MW 312.32 MF C16H16N4O3 N-{(1E)-2-[4-(dimethylamino)phenyl]-1-azavinyl}(4-nitrophenyl)carboxamide
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