MATERIAL SAFETY DATA SHEET for Gossypol: Download MSDS for Gossypol in PDF format
Section 1 - Product Information
Section 2 - Composition/Information on Ingredient
Section 3 - Hazards Identification
Section 4 - First Aid Measures
Section 5 - Fire Fighting Measuresn
Section 6 - Accidental Release Measures
Section 7 - Handling and Storage
Section 8 - Exposure Controls / PPE
Section 9 - Physical/Chemical Properties
Section 10 - Stability and Reactivity
Section 11 - Toxicological Information
Section 12 - Ecological Information
Section 13 - Disposal Considerations
Section 14 - Transport Information
Section 15 - Regulatory Information
Section 16 - Other Information
Section 1 - Product Information
Product Name GOSSYPOL
Product Number ST065835
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
GOSSYPOL 303-45-7 No
Formula C30H30O8
Synonyms 2,2'-Bis(1,6,7-trihydroxy-3-methyl-5-isopropyl-8-a
ldehydonaphthalene) *
8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methyl-2,2
'-bisnaphthalene * Gossypol * Tash 1
RTECS Number: DU3100000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Harmful.
Harmful if swallowed. Limited evidence of a carcinogenic effect.
Possible mutagen. Target organ(s): Male reproductive system.
HMIS RATING
HEALTH: 0*
FLAMMABILITY: 0
REACTIVITY: 0
NFPA RATING
HEALTH: 0
FLAMMABILITY: 0
REACTIVITY: 0
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Water spray.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Section 6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
STORAGE
Store at 2-8°C
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Mechanical exhaust required.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Use respirators and components tested and approved
under appropriate government standards such as NIOSH (US) or CEN
(EU). Where risk assessment shows air-purifying respirators are
appropriate use a dust mask type N95 (US) or type P1 (EN 143)
respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
Section 9 - Physical/Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
Molecular Weight 518.6 AMU
pH N/A
BP/BP Range N/A
MP/MP Range N/A
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density N/A
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Absorption: May be harmful if absorbed through the skin.
Inhalation: May be harmful if inhaled.
Ingestion: Harmful if swallowed.
Multiple Routes: May cause irritation.
TARGET ORGAN(S) OR SYSTEM(S)
Male reproductive system.
SIGNS AND SYMPTOMS OF EXPOSURE
May be irritating to the gastrointestinal tract in experimental
animals. Large doses caused edema of lungs, shortness of breath,
and paralysis.
CONDITIONS AGGRAVATED BY EXPOSURE
The toxicological properties have not been thoroughly
investigated.
TOXICITY DATA
Oral Oral
Rat Rat
2315 mg/kg 2315 mg/kg
LD50 LD50
Oral Oral
Pig Pig
550 mg/kg 550 mg/kg
LD50 LD50
Remarks: Nutritional and Gross Metabolic:Weight loss or
decreased weight gain. Gastrointestinal:Hypermotility, diarrhea.
Behavioral:Muscle weakness. Nutritional and Gross
Metabolic:Weight loss or decreased weight gain.
Gastrointestinal:Hypermotility, diarrhea. Behavioral:Muscle
weakness.
CHRONIC EXPOSURE - MUTAGEN
Species: Human Human
Dose: 10 MG/L 10 MG/L
Cell Type: HeLa cell HeLa cell
Mutation test: DNA inhibition DNA inhibition
Species: Hamster Hamster
Dose: 50 MG/L 50 MG/L
Exposure Time: 48H 48H
Cell Type: lymphocyte lymphocyte
Mutation test: Other mutation test systems Other mutation test
systems
Species: Man Man
Dose: 9 UG/PLATE 9 UG/PLATE
Cell Type: lymphocyte lymphocyte
Mutation test: Cytogenetic analysis Cytogenetic analysis
Species: Man Man
Dose: 1 UG/PLATE 1 UG/PLATE
Cell Type: lymphocyte lymphocyte
Mutation test: Sister chromatid exchange Sister chromatid
exchange
Species: Hamster Hamster
Dose: 10 MG/L 10 MG/L
Cell Type: ovary ovary
Mutation test: DNA inhibition DNA inhibition
Species: Hamster Hamster
Dose: 50 MG/L 50 MG/L
Cell Type: ovary ovary
Mutation test: Other mutation test systems Other mutation test
systems
Species: Hamster Hamster
Dose: 10 MG/L 10 MG/L
Exposure Time: 48H 48H
Cell Type: ovary ovary
Mutation test: Other mutation test systems Other mutation test
systems
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Man Man
Dose: 17 MG/KG 17 MG/KG
Route of Application: Oral Oral
Exposure Time: (60D MALE) (60D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Effects on
Fertility: Male fertility index (e.g., # males impregnating
females per # males exposed to fertile nonpregnant females).
Paternal Effects: Spermatogenesis (including genetic material,
sperm morphology,motility, and count). Effects on Fertility:
Male fertility index (e.g., # males impregnating females per #
males exposed to fertile nonpregnant females).
Species: Rat Rat
Dose: 700 MG/KG 700 MG/KG
Route of Application: Oral Oral
Exposure Time: (35D MALE) (35D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Spermatogenesis (including genetic material, sperm
morphology,motility, and count).
Species: Rat Rat
Dose: 1050 MG/KG 1050 MG/KG
Route of Application: Oral Oral
Exposure Time: (35D MALE) (35D MALE)
Result: Effects on Newborn: Live birth index (# fetuses per
litter; measured after birth). Paternal Effects: Spermatogenesis
(including genetic material, sperm morphology,motility, and
count). Effects on Newborn: Live birth index (# fetuses per
litter; measured after birth). Paternal Effects: Spermatogenesis
(including genetic material, sperm morphology,motility, and
count).
Species: Monkey Monkey
Dose: 4500 MG/KG 4500 MG/KG
Route of Application: Oral Oral
Exposure Time: (90D MALE) (90D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Spermatogenesis (including genetic material, sperm
morphology,motility, and count).
Species: Hamster Hamster
Dose: 525 MG/KG 525 MG/KG
Route of Application: Oral Oral
Exposure Time: (35D MALE) (35D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Spermatogenesis (including genetic material, sperm
morphology,motility, and count).
Species: Hamster Hamster
Dose: 700 MG/KG 700 MG/KG
Route of Application: Oral Oral
Exposure Time: (70D MALE) (70D MALE)
Result: Effects on Fertility: Male fertility index (e.g., #
males impregnating females per # males exposed to fertile
nonpregnant females). Effects on Fertility: Male fertility index
(e.g., # males impregnating females per # males exposed to
fertile nonpregnant females).
Section 12 - Ecological Information
No data available.
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Dissolve or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner and
scrubber. Observe all federal, state, and local environmental
regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: None
Non-Hazardous for Transport: This substance is
considered to be non-hazardous for transport.
IATA
Non-Hazardous for Air Transport: Non-hazardous for air
transport.
Section 15 - Regulatory Information
EU ADDITIONAL CLASSIFICATION
Symbol of Danger: Xn
Indication of Danger: Harmful.
R: 22-40
Risk Statements: Harmful if swallowed. Limited evidence of a
carcinogenic effect.
S: 22-36
Safety Statements: Do not breathe dust. Wear suitable protective
clothing.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Harmful.
Risk Statements: Harmful if swallowed. Limited evidence of a
carcinogenic effect.
Safety Statements: Do not breathe dust. Wear suitable protective
clothing.
US Statements: Possible mutagen. Target organ(s): Male
reproductive system.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: No
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. A+ Scientific.,
shall not be held liable for any damage resulting from handling or
from contact with the above product.
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