Anti-Infectives Library includes 960 low molecular weight, drug-like molecules with scaffolds found in antiseptic agents with anti-bacterial (Gram+ve and Gram-ve), anti-fungoid, anti-microbial activities.

Mechanism	Lattice type
Membrane permeabilizers inhibit bacteria growth	Guanidines
Inhibit cellular respiration and biosynthesis of nucleic acids being acceptors of oxygen	Nitrofurans, Nitroimidazoles
Suppression of bacterial growth by blocking PABA	Sulfonamides
Protein synthesis inhibition in gram-positive microorganisms	Oxazolidinones
Distrupt peptidoglycan layer in the bacterial cell wall	Cephalosporins
Bacteriostatic, IMDH inhibition, anti-PABA, denatures protein while dissolving it	Urea, Diarylurea, Thiourea

 

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