The most fruitful basis for the discovery of a new drug is to start with an old drug.
- James Black
ActiCom is a collection of 480 diverse compounds with known activities. All compounds are classified in general therapeutic categories and have assigned reported activities.
ActiCom is resourceful screening set, an assay development guide, and a good complement to any of our general screening collections. Revisiting known active structures is even more momentous now, when investigators are looking for bi-specific therapeutics and when “rediscovery research” is fueling drug repurposing trend.
Compounds comply with screening purity standards. Active molecules are available in dry form or in DMSO solution and can be delivered in 96 or 384 well plates. Compounds are also available individually or in customized subsets.
Electronic data files with structural information and compound characteristics are available for download
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Shah M, Stebbins JL,et.al.Inhibition of Siah2 ubiquitin ligase by vitamin K3 (menadione) attenuates hypoxia and MAPK signaling and blocks melanoma tumorigenesis.Pigment Cell Melanoma Res. 2009 Dec;22(6):799-808. doi: 10.1111/j.1755-148X.2009.00628.x. Epub 2009 Aug 27.
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Activity Aimed Sets