In XXI century Central Nervous System (CNS) disorders in developed countries outnumber diseases in other therapeutic areas resulting in greater financial strain on healthcare and economies at large. Aging population adds to the trend with steady increase in neurodegenerative diseases and related conditions.

CNS drug development could be the riskiest research area as modern science has relatively limited understanding of precise mechanisms involved in brain diseases and target specific therapies are hard to come by.

With the awareness of selectivity challenge, ActiTarg-CNS, focuses on diverse structural variations and targets primarily three general receptor groups: serotonin, dopamine, and acetylcholine. Each receptor family in its downstream signaling pathways commands broad spectrum of neurological processes.

Serotonin receptors: 5-HT1-2 and 5-HT in general and related
Dopamine receptors: D1-D2 like
Acetylcholine receptors: Nicotinic acetylcholine receptors (nAChR) and Muscarinic acetylcholine receptors (mAChR)
Nonpeptidic caspase inhibitors
 

260 approved and experimental CNS drugs and 77 active molecules common fragments were used in computational tool training to ensure targets-relevant and at the same time highly chemically diverse selection of 3600 compounds suitable for neuropharmaceutical leads discovery.

ActiTarg-CNS 3600 is available for pooling customized subsets in required formatting and as a pre-designed collection in 10mmol concentration.

Related Products

ActiTarg-G GPCR Ligands
ActiTarg-K Kinase Modulators
ActiTarg-P Protease Inhibitors
ActiTarg-S Serpins Inhibitors
ActiTarg-I Potassium Channel Modulators
ActiTarg-N Nuclear Receptor Ligands
ActiTarg-H HDAC Inhibitors 

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Chem-TCM is the digital database of molecules from plants used in the traditional Chinese medicine
MyriaScreen II – diversity screening library from Sigma-Aldrich and TimTec
ApexScreen is a collection of 5,040 compounds that were selected to represent the diversity of TimTec stock
Chemistry reagents, HPLC columns, natural compounds
innovative software packages for chemical database management, chemical web server, structure drawing, diversity analysis, clustering, HTS and combinatorial chemistry, prediction of LogP/solubility/Pk, and Spectra Management