MATERIAL SAFETY DATA SHEET

Download Monastrol MSDS in PDF format

Section 1. Product Information

Product Name

Monastrol

 

Description

reversible, cell-permeable, non-tubulin interacting inhibitor of the mitotic kinesin Eg5 motor protein

IDNUMBER

ST075209

CAS Registry Number

254753-54-3

MDL Number

MFCD00813077

Molecular Formula

C14H16N2O3S

Molecular Weight

292.35

 

Section 2. Hazards Identification

EMERGENCY OVERVIEW

Caution: Avoid contact and inhalation.

 

Section 3 - First Aid Measures

ORAL EXPOSURE

If swallowed, wash out mouth with water provided person is

conscious. Call a physician.

INHALATION EXPOSURE

If inhaled, remove to fresh air. If breathing becomes difficult,

call a physician.

DERMAL EXPOSURE

In case of contact, immediately wash skin with soap and copious

amounts of water.

EYE EXPOSURE

In case of contact with eyes, flush with copious amounts of

water for at least 15 minutes. Assure adequate flushing by

separating the eyelids with fingers. Call a physician.

 

Section 4

EXTINGUISHING MEDIA

Suitable: Water spray. Carbon dioxide, dry chemical powder, or

appropriate foam.

FIREFIGHTING

Protective Equipment: Wear self-contained breathing apparatus

and protective clothing to prevent contact with skin and eyes.

Specific Hazard(s): Emits toxic fumes under fire conditions.

 

Section 5 - Accidental Release Measures

PROCEDURE(S) OF PERSONAL PRECAUTION(S)

Exercise appropriate precautions to minimize direct contact with skin or eyes and prevent inhalation of dust.

METHODS FOR CLEANING UP

Sweep up, place in a bag and hold for waste disposal. Avoid

raising dust. Ventilate area and wash spill site after material pickup is complete.

 

Section 6 - Handling and Storage

HANDLING

User Exposure: Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or repeated exposure.

STORAGE

Suitable: Keep tightly closed.

Store at 2-8°C

SPECIAL REQUIREMENTS

Light sensitive.

 

Section 7 - Exposure Controls / PPE

ENGINEERING CONTROLS

Safety shower and eye bath. Mechanical exhaust required.

PERSONAL PROTECTIVE EQUIPMENT

Respiratory: Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Respiratory protection is not required. Where protection from nuisance levels of dusts are desired, use type N95 (US) or type P1 (EN 143) dust masks.

Hand: Protective gloves.

Eye: Chemical safety goggles.

GENERAL HYGIENE MEASURES

Wash thoroughly after handling.

 

Section 8 - Physical/Chemical Properties

Appearance Physical State: Solid

Property Value At Temperature or Pressure

Molecular Weight 292.4 AMU

 

Section 9 - Stability and Reactivity

STABILITY

Stable: Unstable.

Conditions of Instability: Unstable at room temperature

Materials to Avoid: Strong oxidizing agents.

HAZARDOUS DECOMPOSITION PRODUCTS

Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide, Nitrogen oxides, Sulfur oxides.

HAZARDOUS POLYMERIZATION

Hazardous Polymerization: Will not occur

 

Section 10 - Toxicological Information

ROUTE OF EXPOSURE

Skin Contact: May cause skin irritation.

Skin Absorption: May be harmful if absorbed through the skin.

Eye Contact: May cause eye irritation.

Inhalation: Material may be irritating to mucous membranes and

upper respiratory tract. May be harmful if inhaled.

Ingestion: May be harmful if swallowed.

SIGNS AND SYMPTOMS OF EXPOSURE

Exposure may affect cell growth rate and morphology. To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

 

Section 11 - Disposal Considerations

APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION

Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Observe all federal, state, and local environmental regulations.

 

Section 11 - Transport Information

Non-Hazardous for Transport: This substance is

considered to be non-hazardous for transport.

Non-Hazardous for Air Transport: Non-hazardous for air

transport.

 

Section 12 - Other Information

 

For R&D use only. Not for internal or external human consumption.

 

WARRANTY

THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. TIMTEC SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING OR FROM CONTACT WITH THE ABOVE PRODUCT.

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