Polyphenol C30H30O8 from plants of the Gossypium genus, Malvaceae.
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Supporting information about Gossypol and related molecules can be accessed in the following review, which "summarizes current knowledge about gossypol, its stereochemistry, tautomerism, and the many varied reactions the gossypol molecule can undergo."
James A. Kenar. Reaction Chemistry of Gossypol and Its Derivatives. Review. April 2006. Cereal Products and Food Science Research, NCAUR, ARS, USDA, Peoria, Illinois 61604. J11134 in JAOCS 83, 269–302
Reference: Tripathi AK, et.al. An alpha-proteobacterial type malate dehydrogenase may complement LDH function in Plasmodium falciparum. Cloning and biochemical characterization of the enzyme. Eur J Biochem. 2004 Sep;271(17):3488-502 Conners R, et al. Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase. Mol Biochem Parasitol. 2005 Aug;142(2):137-48 Choi S., et al. Design, Synthesis, and Biological Evaluation of Plasmodium falciparum Lactate Dehydrogenase. J. Med. Chem. 2007, 3841-3850 BioScreening.net: About Gossypol
Definitions of Gossypol - An anticancer drug extracted from the cotton plant - Gossypol is a polyphenol C30H30O8derived from the cottonseed plant (genus Gossypium, family Malvaceae)used as a male oral contraceptive in China. Its efficacy is comparable to the female birth control pill. - A pigment normally found in cotton which gives this crop some resistance to insects Gossypol Biological Properties
Additional information about Gossypol: Gossipol, Gossypol Dipotassium Salt; Gossypol Sodium Salt; Gossypol, (+)-Isomer; Gossypol, (+-)-Isomer; Gossypol, (-)-Isomer; Dipotassium Salt, Gossypol; Sodium Salt, Gossypol. A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer. GOSSYPIUM A plant genus of the family MALVACEAE. It is the source of COTTON FIBER; COTTONSEED OIL, which is used for cooking, and GOSSYPOL. The economically important cotton crop is a major user of agricultural PESTICIDES. Gossypol Derivatives We also offer unique compounds derived from gossypol - Gossypol Derivatives.
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