***now 640 compounds***

TimTec Natural Compounds are a new library of 640 natural compounds composed of pure natural products as lead identifying materials.

• Solids or freshly prepared DMSO solutions
• Diversity by nature
• Purity by science
• Value by design

The Natural Compounds Library (NPL) can be sold as an entire collection or by plate.

Download Natural Product Library Structures

From Rediscovering Natural Products article published in Chemical and Engeneering News, why the interest in natural compounds is increasing:

1. Combinatorial chemistry's promise to fill drug development pipelines with de novo synthetic small-molecule drug candidates is unfulfilled
2. The practical difficulties of natural products drug discovery are being overcome by advances in separation technologies and in the speed and sensitivity of structure elucidation
3. A compelling case is being made for the intrinsic utility of natural products as sources of drug leads.

Read more at Rediscovering Natural products Article

Featured Screening Results for TimTec NPL

TimTec Natural Product Library was screened to identify compounds that significantly reduce infectivity without cytotoxicity. NPL collection counted 280 compounds at the time of the moderate-throughput screening. MTS assay is adaptable to different virus systems.

Out of 280 compounds, 15 molecules showed antiviral activity and were identified as promising models for immunomodulatory agents.

Shaneyfelt, M. E., et al. Natural products that reduce rotavirus infectivity identified by a cell-based moderate-throughput screening assay. Virology Journal, 2006, 3:68doi:10.1186/1743-422X-3-68

The electronic version of this article is the complete one and can be found online at: http://www.virologyj.com/content/3/1/68 and http://www.virologyj.com/content/3/1/68/table/T1

Download available compounds that reduce rotavirus infectivity without cytotoxicity.

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"We recently published our paper on the AhR and utilized your NPL library as part of a physical and virtual screen.  Here is the link:
http://pubs.acs.org/doi/abs/10.1021/jm900199u

Thanks for all your help, and if any of your scientists need any help understanding what we did, feel free to contact me again."

Dan Koch

Bisson H., et.al. Modeling of the Aryl Hydrocarbon Receptor (AhR) Ligand Binding Domain and Its Utility in Virtual Ligand Screening to Predict New AhR Ligands. J.Med. Chem. 2009 Sept, 52 (18), 5635-5641.

View available from stock activators of AhR transcription based on initial in silico screening

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Jadhav A., et al. Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease. J Med Chem. 2010 Jan 14;53(1):37-51.

NPL is one of TimTec nature-inspired collections. Natural Derivatives Library, NDL-3000, elaborates on structural diversity of pure natural molecules and includes natural derivatives, analogs, semi-natural compounds, and mimics. There is no compound overlap between NPL and NDL.

Learn more about Natural Derivatives Library design approach.

Related Information

Natural Product Reports article

TimTec pure Natural Products Library, NPL, includes primarily known natural compounds that are also available through a number of domestic and international commercial sources. The value of the library design is in the broad diversity of selected natural material available in screen-ready format. TimTec does not hold any IP rights for compounds in any of our collections nor is responsible for any sort of damages that may result from TimTec products use. TimTec products are for R&D use only and should be handled by trained personnel.