ST060266 Order online ST078925 Order online ST045849 Order online

MW: 289.67

phenyl 5-chloro-2-oxo-3-hydrobenzoxazole-3-carboxylate

 

MW: 406.53

4-[(3-cyano-4-(2-thienyl)-2-5,6,7,8-tetrahydroquinolylthio)methyl]benzoic acid

ST078925 analog-substitute to validated inhibitor #6, Figure 3. of the paper

 

MW: 447.00

3-(2-adamantanylethyl)-2-[(4-chlorophenyl)azamethylene]-4-oxo-1,3-thiazaperhyd roine-6-carboxylic acid ; 2H-1, 3-thiazine-6-carboxylicacid, 2-[(4-chlorophenyl) imino] tetrahydro-4-oxo-3-(2-tricyclo[3.3.1.13, 7] dec-1-ylethyl-)

OGT inhibitor, ST045849, TT04,
treatment reduces beta-cell development:
     

Contact us to order Please list required amounts.

Prices before shipping are 0.1mg/$58.00, 0.5mg/$79.00, 1mg/$90.00, 2mg/$145.00, 3mg/$160.00, 5mg/$175.00 per compound

In addition, TimTec assembled small targeted compound collection of over 300 compounds-analogs based on three validated O-GlcNAc Transferase inhibitors (following the results of the discovery at Department of Microbiology and Molecular Genetics, HUMS)

Reference:

Gross, B.J, Kraybill, B.C., Walker, S. Discovery of O-GlcNAc Transferase Inhibitors. Department of Microbiology and Molecular Genetics, Harvard Medical School. JACS Communications, published on Web 09/29/05; J. Am. Chem. Soc. 2005, 127, 14588-14589.

Discovery of O-GlcNAc Transferase Inhibitors Harvard Medical School

Filhoulaud, G., et al. The hexosamine biosynthesis pathway is essential for pancreatic beta cell development. J Biol Chem. 2009 Sep 4;284(36):24583-94.

Zafir A., Readnower R., et.al. Protein O-GlcNAcylation is a Novel Cytoprotective Signal in Cardiac Stem Cells. Stem Cells. 2012 April; 31(4): 765–775.

Compound Search

Site Search

share

FacebookTwitterLinkedin

Contact Us

Toll Free 800-574-7391
Phone: 302-292-8500
Fax: 302-292-8520

TimTec in Russia

TimTec in China

Chem-TCM is the digital database of molecules from plants used in the traditional Chinese medicine
MyriaScreen II – diversity screening library from Sigma-Aldrich and TimTec
ApexScreen is a collection of 5,040 compounds that were selected to represent the diversity of TimTec stock
Chemistry reagents, HPLC columns, natural compounds
innovative software packages for chemical database management, chemical web server, structure drawing, diversity analysis, clustering, HTS and combinatorial chemistry, prediction of LogP/solubility/Pk, and Spectra Management

Site Search