These groups of compounds possess structural features and molecular lattices that are representative of agents described in the patent and/or technical literature with the activity designated below. In addition, medicinal chemistry judgment has also been implemented in the selection process to provide libraries that promise lead identification in an expedited manner. These groups have also been filtered to contain only those compounds that fall within favorable molecular weight parameters.
Currently available libraries
Low molecular weight drug-like compounds with fragments found in known non-steroidal anti-inflammatory drugs
Low molecular weight, drug-like molecules with scaffolds found in agents with the indicated activity have been assembled.
O-GlcNAc Transferase Inhibitors
A small targeted compound collections of over 150 compounds-analogs based on three validated O-GlcNAc Transferase inhibitors (following the results of the discovery at Department of Microbiology and Molecular Genetics, HUMS)
Activators of Neutrophils
Compounds affecting neutrophil function.
Inhibitors of Anthrax LF
Compounds inhibiting Anthrax Lethal Factor
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