Privileged Structure Library

Evaluation of the chemical structures of commercially available pharmaceuticals and agents with good pharmacological activity led to identification of molecular motifs that are more frequently associated with higher biological activity than other substructures. These motifs were given the "privileged" label when they were found to be present in molecules that were active at two or more different receptors. The interpretation was that the privileged fragment provided the scaffold, and the substituents the specificity for a particular target. TimTec has assembled groups of privileged structures that can be excellent starting points for the identification of small molecule leads. All sets are immediately available as dry powder or in DMSO. Benzhydryl -- 320 compounds (4 plates) Biphenyl -- 400 compounds (5 plates) Aza-(and diaza-)biphenyl -- 480 compounds (6 plates) Dihydropyridine -- 960 compounds (12 plates) Anilino-pyridine, pyrimidine, or triaz-ine -- 240 compounds (3 plates) Phenylpiperazine -- 960 compounds (12 plates)