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Polyphenol C30H30O8 from plants of the Gossypium genus, Malvaceae.
Molecular Weight: 518.6
Melting Point: 177-182°C (decomp.)
Purity min.: 98%
CAS Number: 303-45-7
IDNUMBER: ST065835
Gossypol is available for large-scale (1, 10, 100 kg) production at our facilities.
Please contact us for more information.  Gossypol 
About Gossypol, Definitions of Gossypol
- An anticancer drug extracted from the cotton plant
- Gossypol is a polyphenol C30H30O8derived from the cottonseed plant (genus Gossypium, family Malvaceae)used as a male oral contraceptive in China. Its efficacy is comparable to the female birth control pill.
- A pigment normally found in cotton which gives this crop some resistance to insects Gossypol Biological Properties - A polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
- Gossypol is antimalarial being the selective inhibitor of Plasmodium falciparum (pfLDH over hLDHs), an essential enzyme for energy generation within malarial parasite.
- Posesses proapoptotic properties, probably due to the regulation of the Bax and Bcl2.
- Reversibly inhibits Calcineurin and binds to calmodulin.
- Inhibits replication of the HIV-1 virus.
- An effective protein kinase C inhibitor.
Additional information about Gossypol:
Gossipol, Gossypol Dipotassium Salt; Gossypol Sodium Salt; Gossypol, (+)-Isomer; Gossypol, (+-)-Isomer; Gossypol, (-)-Isomer; Dipotassium Salt, Gossypol; Sodium Salt, Gossypol.
A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
GOSSYPIUM
A plant genus of the family MALVACEAE. It is the source of COTTON FIBER; COTTONSEED OIL, which is used for cooking, and GOSSYPOL. The economically important cotton crop is a major user of agricultural PESTICIDES. Reference: Tripathi AK, et.al. An alpha-proteobacterial type malate dehydrogenase may complement LDH function in Plasmodium falciparum. Cloning and biochemical characterization of the enzyme. Eur J Biochem. 2004 Sep;271(17):3488-502 Conners R, et al. Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase. Mol Biochem Parasitol. 2005 Aug;142(2):137-48 Choi S., et al. Design, Synthesis, and Biological Evaluation of Plasmodium falciparum Lactate Dehydrogenase. J. Med. Chem. 2007, 3841-3850 BioScreening.net: About Gossypol
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