Compound Selection

Formula: C21H27ClN2O3

MW: 390.91

CAS: 6211-32-1

MDL: MFCD06668052

TNP: TNP00156

YOHIMBINE HCL, ALPHA-; 20-alpha-yohimban-16-beta-carboxylicacid,17-alpha-hydroxy-,methylester,hyd; alpha-yohimbinhydrochloride; RAUWOLFSCINE HYDROCHLORIDE; RAUWOLSCINE; RAUWOLSCINE HCL; RAUWOLSCINE HYDROCHLORIDE; ISOYOHIMBINE

LogP: -2

LogS: -1.69

Acceptors: 3

Donors: 2

Rotation Bonds: 1

Chiral Centers: 5

N+O: 5


Info: water


Smiles: c1c2c3c([nH]c2ccc1)[C@H]1(N(CC3)C[C@@H]2([C@H](C1)([C@H](C(OC)=O)[C@H](CC2)O))).Cl

Physiol Action: alpha2-adrenoceptor antagonist; 5-HT1A serotonin receptor agonis

THERAPEUTIC CATEGORY: Alpha-adrenergic blocker; mydriatic


SOURCE: Found in Coryanthe johime K. Shchum., Rubaceae and related trees, also in Rauwolfia serpentina (L.,) Benth., Apocynaceae

Specification: Adrenoceptor RAUWOLSCINE HYDROCHLORIDE Chemical Properties:

mp 270-280C storage temp. Store at RT solubility H2O: soluble form solid color white Safety Information Hazard Codes T Risk Statements 23/24/25 Safety Statements 22-36/37/39-45 RIDADR UN 1544 6.1/PG 2 WGK Germany 3 RTECS ZG1035000 RAUWOLSCINE HYDROCHLORIDE Usage And Synthesis Biological ActivityStandard a 2 -adrenergic antagonist (K i values are 3.5, 4.6 , and 0.6 nM at cloned human a 2A , a 2B , and a 2C -adrenoceptors respectively). Partial agonist at 5-HT 1A receptors. Also available as part of the a 2 -Adrenoceptor Tocriset

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