Chemical Compounds
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Natural Compounds
Featured Natural Products/Compounds
Monastrol (ST075209) Cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC50=14µM) by binding to the mitotic kinesin Eg5. 
Genipin (ST080860) Genipin is an aglycone derived from an iridoid glycoside called geniposide present in fruit of Gardenia jasmindides Ellis. Genipin is an excellent natural cross-linker for proteins, collagen, gelatin, and chitosan cross-linking. 
Anabasine Hydrochloride (ST069297)
Insecticide Biomarker Inhibitors of breast cancer aromatase VET: anabasin hydrochloride has no teratogenic properties VET: inhibited rat adrenal mitochondrial 11 beta-hydroxylase and microsomal 21-hydroxylase
Cytisine (ST008373)
Potent ligand for many nAChR subtypes. Known for analgesic, antihypertensive and inotropic activities. partial agonist of high-affinity nicotinic acetylcholine receptors
Gossypol (ST065835)
Exhibits multiple biological effects including antifertility and anticancer activity.
Gramine (ST023280)
Vasorelaxing agent acting mainly by antagonism at 5-HT (2A) receptors Toxic to cells, may play defensive role in plants
Harman (ST013856)
Possesses antiplasmodial activity associated with a low cytotoxicity Monoamine oxidase (MAO) inhibitor inhibit HIV replication in H9 lymphocyte cells Antibiotic
Lagochiline (ST059290)
Sedative, hemostatic, hypotensitive effects
Levoglucosenone (ST005503)
Initiates tumor and shows clastogenic activity in mice
Lupinine (ST018409)
Antialcoholic affect: reduces aethanol anesthesia
Salsolidine (ST023755)
Competitive inhibitor of catechol-O-methyltransferase Stereoselective competitive inhibitor of the enzyme monoamine oxidase
Solasodine (ST023803)
Antiinflammatory activity Steroidal alkaloid solasodine is linked to impaired female sexual behavior of rat offspring Antiproliferative activities against human colon (HT29) and liver (HepG2) cancer cellsView entire listing of natural compounds
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Read more about TimTec selection of Natural Products - BioActive Compounds
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Novel BH4-BCL-2 Domain Antagonists Induce BCL-2-Mediated Apoptosis in Triple-Negative Breast CancerSimple Summary Our work has led to the identification of three novel BH4 mimetics, SM216, SM396, and SM949, with nanomolar activities both in vitro and in vivo assays. SM396 binds covalently to the BH4 domain of BCL-2 while the compounds SM216 and SM949 are non-covalent BH4 binders. Our results illustrate that these compounds are highly specific to the triple-negative breast cancer cells with no...
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New Florida LocationMay 2019: TimTec have moved to Tampa, Florida.
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Natural Product Library is now composed of 800 pure natural compounds: NPL-800One more plate is added to the pure Natural Products Library making it NPL-800 compounds. Tap natural bioactivity potential with molecules that are primarily sourced from plants with the remaining samples from bacteria, fungus, and animal sources. TimTec NPL, Natural Product Library, is now composed of 800 pure natural compounds as lead identifying material. Natural molecules tend to be multi-active...
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Privileged Structures: Mesoionic, Aminomorpholines, and Dihydropyridines Some molecular motifs are associated with higher biological activity and are given the "privileged" label when found in molecules that are active at two or more different receptors. Revisiting privileged structures is even more momentous now, when investigators are looking for bi-specific therapeutics and when “rediscovery research” is fueling drug repurposing (1,2). TimTec new selection of... -
FBL-3,200 Fragment-Based Library
Fragments.Rainer Mutsch‘s abstract installation, 2006. Molecular fragment as a part of something yet invisible and more functional structural whole defines Fragment-Based Drug Discovery (FBDD) being used more and more on its own and along with HTS campaigns. FBDD is well established by now with the first fragment-based screening drug being approved, Zelboraf (vemurafenib). FBDD is credited...
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Natural Product Library is now composed of 800 pure natural compounds: NPL-800
One more plate is added to the pure Natural Products Library making it NPL-800 compounds. Tap natural bioactivity potential with molecules that are primarily sourced from plants with the remaining samples...
Read More...Ancient Chinese cures translate into modern Western medicines
China Daily. November 22, 2011. By Cecily Liu
The Chem-TCM is the most comprehensive database of its kind and translates more than 12,000 chemicals from more than 300 Chinese herbs used in traditional...
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ActiCom-480, active compounds with known activities
ActiCom is TimTec collection of 480 compounds with known activities. All compounds are classified in general therapeutic...
Read More...Inhibitors of Anthrax LF and Activators of Neutrophils
Inhibitors of Anthrax LF and Activators of Neutrophils are available now. Inhibitors of Anthrax LF Product Page Activators...
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