ST056351 Rauwolscine hydrochloride, Methyl-(16B,17a,20a)-17-hydroxyyohimban-16-carboxylathydrochlorid

MW: 390.91

CAS: 6211-32-1

TNP NUMBER: TNP00156

MDL NUMBER: MFCD06668052

Smiles: c1c2c3c([nH]c2ccc1)[C@H]1(N(CC3)C[C@@H]2([C@H](C1)([C@H](C(OC)=O)[C@H](CC2)O))).Cl

THERAPEUTIC CATEGORY: Alpha-adrenergic blocker; mydriatic

VET THERAP CATEGORY: Adrenergic blocker. Has been used as aphrodisiac

SOURCE: Found in Coryanthe johime K. Shchum., Rubaceae and related trees, also in Rauwolfia serpentina (L.,) Benth., Apocynaceae

ACCEPTORS: 3

DONORS: 2

ROTATION BONDS: 1

N+O: 5

Chiral Centers: 5

LogP: 5.06

LogS: -5.27

LIPINSKI: 4

Synonyms: YOHIMBINE HCL, ALPHA-;20-alpha-yohimban-16-beta-carboxylicacid,17-alpha-hydroxy-,methylester,hyd;alpha-yohimbinhydrochloride;RAUWOLFSCINE HYDROCHLORIDE;RAUWOLSCINE;RAUWOLSCINE HCL;RAUWOLSCINE HYDROCHLORIDE;ISOYOHIMBINE

CAS:6211-32-1

MF:C21H27ClN2O3

MW:390.9

EINECS:228-279-6

Product Categories:Adrenoceptor RAUWOLSCINE HYDROCHLORIDE

Chemical Properties: mp 270-280C storage temp. Store at RT solubility H2O: soluble form solid color white T Risk Statements 23/24/25 Safety Statements 22-36/37/39-45 RIDADR UN 1544 6.1/PG 2 WGK Germany 3 RTECS ZG1035000 RAUWOLSCINE HYDROCHLORIDE

Usage And Synthesis: Biological ActivityStandard a 2 -adrenergic antagonist (K i values are 3.5, 4.6 , and 0.6 nM at cloned human a 2A , a 2B , and a 2C -adrenoceptors respectively). Partial agonist at 5-HT 1A receptors. Also available as part of the a 2 -Adrenoceptor Tocriset . RAUWOLSCINE HYDROCHLORIDE

Chemical Compounds - BioActive Compounds