Compound Selection

Formula: C20H16N2O4

MW: 348.36

CAS: 2114-45-4, 7689-03-4



IUPAC: (4S)-4-ethyl-4-hydroxy-4,12-dihydro-1H-pyrano[3,4-f]quinolino[2,3-a]indolizine -3,14-dione

Smiles: n12c(c3nc4ccccc4cc3C2)cc2C(C(=O)OCc2c1=O)(O)CC

THERAPEUTIC CATEGORY: Antitumor alkaloid; prototype DNA topoisomerase I inhibitor.

REFERENCE: Reference Fan, Y., et al., Molecular modeling studies of the DNA-topoisomerase I ternary cleavable complex with camptothecin. J. Med. Chem. 41, 2216-2226, (1998) abstract Morris. E.J., and Geller, H.M., Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity. J. Cell Biol. 134, 757-770, (1996) abstract Kaufmann, S. H., Cell death induced by topoisomerase-targeted drugs: more questions than answers. Biochim. Biophys. Acta 1400, 195-211, (1998) abstract Borovitskaya, A.E., and D-Arpa, P., Replication-dependent and -independent camptothecin cytotoxicity of seven human colon tumor cell lines. Oncol. Res. 10, 271-276, (1998) abstract Pommier, Y., et al., Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme. Biochim. Biophys. Acta 1400, 83-105, (1998) abstract Desai, S. D., et al., Ubiquitin-dependent destruction of topoisomerase I is stimulated by the antitumor drug camptothecin. J. Biol. Chem. 272, 24159-24164, (1997) abstract Beidler, D.R., and Cheng, Y.C., Camptothecin induction of a time- and concentration-dependent decrease of topoisomerase I and its implication in camptothecin activity. Mol. Pharmacol. 47, 907-914, (1994) Merck Merck 13,1743 reference FT-IR 2 (3), 4267:D / Structure Index 1, 462:C:1

SOURCE: Isolation from stem wood of the Chinese tree, Camptotheca acuminata Decsne., Nyssaceae




N+O: 6

Chiral Centers: 1

LogP: 3.07

LogS: -4.47


Monograph Number: 0001743

Title: Camptothecin

CAS Registry Number: 7689-03-4

CAS Name: (S)-4-Ethyl-4-hydroxy-1H-pyrano[3

Chemical Compounds - BioActive Compounds

Structure Search Shop Online Download Databases Request a CD
Structure Search eChemStore Download Request CD

Site Search

Compound Search



Contact Us

Phone: 302-292-8500
Fax: 302-292-8520

Chem-TCM is the digital database of molecules from plants used in the traditional Chinese medicine
MyriaScreen II – diversity screening library from Sigma-Aldrich and TimTec
ApexScreen is a collection of 5,040 compounds that were selected to represent the diversity of TimTec stock
Chemistry reagents, HPLC columns, natural compounds
innovative software packages for chemical database management, chemical web server, structure drawing, diversity analysis, clustering, HTS and combinatorial chemistry, prediction of LogP/solubility/Pk, and Spectra Management