MW: 167.21
Salt: HCl
CAS: 61-76-7
MDL NUMBER: MFCD00063028
IUPAC: 1-(3-hydroxyphenyl)-2-(methylamino)ethan-1-ol
Smiles: c1cc(cc(c1)O)C(CNC)O
L(-)-Phenylephrine hydrochloride 99%
THERAPEUTIC CATEGORY: Phenylephrine or neosynephrine is an ?-adrenergic receptor agonist used primarily as a decongestant, as an agent to dilate the pupil, and rarely to increase blood pressure.
ACCEPTORS: 2
DONORS: 3
ROTATION BONDS: 5
N+O: 3
Chiral Centers: 1
LogP: 0.54
LogS: -2.63
LIPINSKI: 4
Synonyms: (-)-alpha-hydroxy-beta-(methylamino)ethyl-alpha-(3-hydroxybenzene)hydrochlor;1-m-hydroxy-alpha-(methylaminomethyl)benzylalcoholhydrochloride;3-hydroxy-alpha-((methylamino)methyl)-,hydrochloride,(-)-benzenemethano;almefrin;benzenemethanol,3-hydroxy-alpha-[(methylamino)methyl]-,hydrochloride,(thet;consdrin;consdrinhydrochloride;d-(-)-phenylephrinehydrochloride
CAS:61-76-7
MF:C9H14ClNO2
MW:203.67
EINECS:200-517-3
Product Categories: Phenylephrine hydrochloride
Chemical Properties: mp 143-145 C(lit.) alpha -47 (c=2, H2O) refractive index -45.5 (C=1, H2O) storage temp. Desiccate at RT Water Solubility >=10 g/100 mL at 21 C Merck 7286
CAS DataBase Reference: 61-76-7(
CAS DataBase Reference: ) EPA Substance Registry SystemBenzenemethanol, 3-hydroxy-.alpha.-[(methylamino) methyl]-, hydrochloride, (.alpha.R)-(61-76-7) Xn Risk Statements 22-36/37/38 Safety Statements 26-36-37/39 RIDADR 3249 WGK Germany 3 RTECS DO7525000 HazardClass 6.1(b) PackingGroup III (R)-(-)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride Phenylephrine hydrochloride
Usage And Synthesis:
Chemical Properties: white to almost white crystalline powder General DescriptionOdorless white microcrystalline powder. Bitter taste. pH (1% aqueous solution) about 5. Air & Water ReactionsMay be sensitive to prolonged exposure to air and light. Water soluble. Reactivity ProfilePhenylephrine hydrochloride is incompatible with acids, acid chlorides, acid anhydrides and oxidizing agents. Phenylephrine hydrochloride is also incompatible with butacaine, alkalis and ferric salts. Fire HazardFlash point data for Phenylephrine hydrochloride are not available; however, Phenylephrine hydrochloride is probably combustible. Biological Activitya 1 -adrenoceptor agonist; pK i values are 5.86, 4.87 and 4.70 for a 1D , a 1B and a 1A receptors respectively. Phenylephrine hydrochloride
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