
This activity-aimed set includes low molecular weight drug-like compounds with fragments found in known non-steroidal anti-inflammatory drugs covering variety of targets.
About 20 starting drugs fragments are used to assemble the set of 1950 compounds available in 10mmol or 1mg/1mL concentrations and in dry form.
Fragmental representation is summarized in the table below. Custom sub-sets can be created to narrow or expand the pre-designed selection.
Lattice type |
Lattice Type Occurrence |
Drug Example |
Aryl acetic acids |
353 |
Acemetacin, Felbinac |
Quinolines |
300 |
GSK256066, Compound 35 (Kyowa Hakko Kirin), Compound 19 (BMS) |
Amino aryl carboxylic acid |
141 |
Etofenamate, Talniflumate |
Aryl carboxylic acid derivatives |
705 |
Clidanac, Tinoridine |
Aryl butyric acid derivatives |
24 |
Bumadizon, Fenbufen |
Aryl propionic acid derivatives |
158 |
Ibuprofen, Suprofen, Oxaprozin |
Pyrazoles |
680 |
Difenamizole, Epirizole |
Pyrazolones |
586 |
Propyphenazone, Suxibuzone |
Salicylic acid |
71 |
Aspirin, Diflunisal,Parsalmide, Olsalazine |
2-hydroxyacetic acid |
3 |
Benzydamine |
1,3,5-trihydropyrimidine-2,4,6-trione |
26 |
Bucolome |
N-(2-pyridyl)carboxamide |
272 |
Difenpiramide |
1,3-oxazole-2-ylamine |
4 |
Ditazol |
2-amino-1-phenylethan-1-ol |
28 |
Fepradinol |
methanesulfonamide, thiazinecarboxamide |
106 |
Nimesulide, Lexipafant |
9-methylenefluorene |
3 |
Paranyline |
3,4,5-trihydropyrimidin-2-one |
3 |
Proquazone |