ST056295 Sinomenine

MW: 329.4

Salt: 0.3CHCl3

CAS: 115-53-7

MDL: MFCD01103301

TNP: TNP00111

7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-9-alpha,13-alpha,14-alpha-mo; 9-alpha,13-alpha,14-alpha-morphinan-6-one,7,8-didehydro-4-hydroxy-3,7-dimethox; rphinan-6-one; y-17-methyl-; SABIANINE A; SINOMENIN; SINOMENINE; (9alpha,13alpha,14alpha)-7,8-didehydro-

LogP: 6.73

LogS: -5.43

Acceptors: 4

Donors: 1

Rotation Bonds: 3

Chiral Centers: 3

N+O: 5

LIPINSKY: 3

IUPAC: (9S,10S,1R)-3-hydroxy-4,12-dimethoxy-17-methyl-17-azatetracyclo[7.5.3.0<1,10>. 0<2,7>]heptadeca-2,4,6,11-tetraen-13-one

Smiles: c12C34C(C=C(C(C3)=O)OC)C(Cc1ccc(c2O)OC)[N@](CC4)C

Specification: Alkaloids; Natural Plant Extract; Asymmetric Synthesis; Chiral Building Blocks; Complex Molecules Sinomenine Chemical Properties:

mp 180 C (dec.)(lit.) storage temp. Store at +4C Merck 13,8620 Safety Information Hazard Codes T Risk Statements 45-46-23/24/25-36/37/38-20/21/22 Safety Statements 53-22-26-36/37/39-45 RIDADR 1544 WGK Germany 3 RTECS QD2170000 F 9 HazardClass 6.1(b) PackingGroup III (9alpha,13alpha,14alpha)-7,8-Didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one English Sinomenine Usage And Synthesis Biological ActivityNatural anti-inflammatory morphinan analog. Causes degranulation of mast cells in mammalian tissues to release histamine and suppresses production of proinflammatory cytokines. Also displays antinociceptive activity, possibly through activation of the

Chemical Compounds - Natural Compounds