Compound Selection

Formula: C14H19NO4

MW: 265.31

CAS: 22862-76-6

TNP NUMBER: TNP00269

MDL NUMBER: MFCD06668135

IUPAC: 4-hydroxy-2-[(4-methoxyphenyl)methyl]pyrrolidin-3-yl acetate

Smiles: COc1ccc(CC2[C@H](OC(=O)C)[C@H](CN2)O)cc1

THERAPEUTIC CATEGORY: Antiprotozoal (Trichomonas)

REFERENCE: Reference Alberts, B., et al., Basic genetic mechanisms in molecular biology of the cell. Cell 3rd ed., New York, NY , 240, (1994) Faris, M., et al., The c-Jun N-terminal kinase cascade plays a role in stress-induced apoptosis in Jurkat cells by up-regulating Fas ligand expression. J. Immunol. 160, 134-144, (1998) abstract Polverino, A.J., Patterson, S.D., Selective activation of caspases during apoptotic induction in HL-60 cells. Effects of a tetrapeptide inhibitor. J. Biol. Chem. 272, 7013, (1997) abstract Zechner, D., et al., MKK6 activates myocardial cell NF-kappaB and inbibits apoptosis in a p38 mitogen-activated protein kinase-dependent manner. J. Biol. Chem. 273, 8232-8239, (1998) abstract Barros, L.F., et al., Evidence of two mechanisms for the activation of the glucose transporter GLUT1 by anisomycin: p38(MAP kinase) activation and protein synthesis inhibition in mammalian cells. J. Physiol. 504, 517-525, (1997) abstract Hoffman, M.E., et al., Inhibition of protein synthesis and amino acid transport by crystal violet in Trypanosoma cruz. J. Eukaryot. Microbiol. 42, 293-297, (1995) abstract Barancik, M., et al., Okadaic acid and anisomycin are protective and stimulate the SAPK/JNK pathway. J. Cardiovasc. Pharmacol. 34, 182-190, (1999) abstract Liao, J., et al., Stress apoptosis and mitosis induce phosphorylation of human keratin 8 at Ser-73 in tissues and cultured cells. J. Biol. Chem. 272, 17565, (1997) abstract Merck Merck 13,673 Beilstein Beil. 21,V,5,523

SOURCE: Antibiotic isolated from Streptomyces griseolus

ACCEPTORS: 4

DONORS: 2

ROTATION BONDS: 2

N+O: 5

Chiral Centers: 3

LogP: 1.1

LogS: -3.36

LIPINSKI: 4

Chemical Compounds - BioActive Compounds

Structure Search Shop Online Download Databases Request a CD
Structure Search eChemStore Download Request CD

Site Search

Compound Search

share

FacebookTwitterLinkedin

Contact Us

Toll Free 800-574-7391
Phone: 302-292-8500
Fax: 302-292-8520

Chem-TCM is the digital database of molecules from plants used in the traditional Chinese medicine
MyriaScreen II – diversity screening library from Sigma-Aldrich and TimTec
ApexScreen is a collection of 5,040 compounds that were selected to represent the diversity of TimTec stock
Chemistry reagents, HPLC columns, natural compounds
innovative software packages for chemical database management, chemical web server, structure drawing, diversity analysis, clustering, HTS and combinatorial chemistry, prediction of LogP/solubility/Pk, and Spectra Management