Compound Selection

Formula: C15H10O5

MW: 270.24

CAS: 491-67-8

TNP NUMBER: TNP00121

MDL NUMBER: MFCD00017459

IUPAC: 5,6,7-trihydroxy-2-phenylchromen-4-one

Smiles: c12c(cc(c3ccccc3)oc2cc(c(c1O)O)O)=O

THERAPEUTIC CATEGORY: Astringent

REFERENCE: Merck Index, 12th Ed., 971

SOURCE: From root of Scutellaria baicalensis

ACCEPTORS: 5

DONORS: 3

ROTATION BONDS: 3

N+O: 5

Chiral Centers: 0

LogP: 1.74

LogS: -3.3

LIPINSKI: 4

Synonyms: 5,6,7-TRIHYDROXY-2-PHENYL-(4H)-1-BENZOPYRAN-4-ONE;5,6,7-TRIHYDROXYFLAVONE;4H-1-BENZOPYRAN-4-ONE,5,6,7-TRIHYDROXY-2-PHENYL-;BAICALEIN, 98+% BY HPLC;BAICALEIN4H-1-BENZOPYRAN-4-ONE,5,6,7-TRIHYDROXY-2-PHENYL-,;Baicalein std.;5,6,7-Trihydroxyflavone,97%;Baicaleine

CAS:491-67-8

MF:C15H10O5

MW:270.24

EINECS:

Product Categories:Tri-substituted Flavones;The group of Scutellaria;Inhibitors Baicalein

Chemical Properties: mp 256-271 C(lit.) storage temp. 2-8C Merck 14,942 BRN 272683

CAS DataBase Reference: 491-67-8(

CAS DataBase Reference: ) Xi,Xn Risk Statements 36/37/38-20/21/22 Safety Statements 26-36 WGK Germany 3 Hazard Note Irritant Baicalein

Usage And Synthesis:

Chemical Properties: Yellow Crystalline Solid UsageAn inhibitor of 12-lipoxygenase, leukotriene biosynthesis and release of lysosomal enzymes. It also inhibits cellular Ca2+ uptake and mobilization and adjuvant-induced arthritis. Baicalein is the flavonoid component of Nepalese and Sino-Japanese crude d Biological ActivityInhibitor of 5- and platelet 12-lipoxygenases (IC 50 values are 9.5 and 0.12 mM respectively). Also inhibits Raf-mediated MEK-1 phosphorylation in C6 rat glioma cells and induces G1 and G2 cell cycle arrest by decreasing cdk1, cdk2, cyclin D2 and cyclin A expression. Anti-inflammatory in vivo . Baicalein

Chemical Compounds - BioActive Compounds

Structure Search Shop Online Download Databases Request a CD
Structure Search eChemStore Download Request CD

Site Search

Compound Search

share

FacebookTwitterLinkedin

Contact Us

Toll Free 800-574-7391
Phone: 302-292-8500
Fax: 302-292-8520

Chem-TCM is the digital database of molecules from plants used in the traditional Chinese medicine
MyriaScreen II – diversity screening library from Sigma-Aldrich and TimTec
ApexScreen is a collection of 5,040 compounds that were selected to represent the diversity of TimTec stock
Chemistry reagents, HPLC columns, natural compounds
innovative software packages for chemical database management, chemical web server, structure drawing, diversity analysis, clustering, HTS and combinatorial chemistry, prediction of LogP/solubility/Pk, and Spectra Management