Natural Compound Library

Charles L. Sawyers

TimTec NPL (Natural Product Library) is a library of 720 natural compounds composed of pure natural products as lead identifying materials.

NPL is sold either as a complete collection or by plate; available in solid form or DMSO solution. NPL Structural Info

Rediscovering Natural products Article: Interest in natural compounds is on the rise.

1. Combinatorial chemistry's promise to fill drug development pipelines with de novo synthetic small-molecule drug candidates is unfulfilled
2. The practical difficulties of natural products drug discovery are being overcome by advances in separation technologies and in the speed and sensitivity of structure elucidation
3. A compelling case is being made for the intrinsic utility of natural products as sources of drug leads.

TimTec NPL Featured Screening Results

TimTec Natural Product Library was screened to identify compounds that significantly reduce infectivity without cytotoxicity. NPL collection featured 280 compounds at the time of the moderate-throughput screening. MTS assay is adaptable to different virus systems.

Out of 280 compounds, 15 molecules showed antiviral activity and were identified as promising models for immunomodulatory agents.

Shaneyfelt, M. E., et al. Natural products that reduce rotavirus infectivity identified by a cell-based moderate-throughput screening assay. Virology Journal, 2006, 3:68doi:10.1186/1743-422X-3-68

Download available compounds that reduce rotavirus infectivity without cytotoxicity.

*    *    *

"We recently published our paper on the AhR and utilized your NPL library as part of a physical and virtual screen.Thanks for all your help, and if any of your scientists need any help understanding what we did, feel free to contact me again."        - Dan Koch

Bisson H., et.al. Modeling of the Aryl Hydrocarbon Receptor (AhR) Ligand Binding Domain and Its Utility in Virtual Ligand Screening to Predict New AhR Ligands. J.Med. Chem. 2009 Sept, 52 (18), 5635-5641.  

View available from stock activators of AhR transcription based on initial in silico screening

*    *    *

Jadhav A., et al. Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease. J Med Chem. 2010 Jan 14;53(1):37-51.

NPL is one of TimTec nature-inspired collections. Natural Derivatives Library (NDL-3000) elaborates on structural diversity of pure natural molecules and includes natural derivatives, analogs, semi-natural compounds, and mimics. There is no overlap between NPL and NDL compounds.

Learn more about the Natural Derivatives Library design approach.

Related Information

Natural Product Reports article 

TimTec Pure Natural Products Library (NPL) includes primarily known natural compounds that are also available through a number of domestic and international commercial sources. The value of the library design is in the broad diversity of selected natural material available in screen-ready format. TimTec does not hold any intellectual property (IP) rights for compounds in our collections nor is responsible for any damages that may result from TimTec products use. TimTec products are for R&D use only and should be handled by trained personnel.